Compounded Semaglutide: Uses, Side Effects, and FAQs

Medically reviewed by:Angelique Tongson, MD
Written by: Chloie RayosoEdited by: Arsenio Armas
Updated: August 1, 20253 min read

Key Takeaways

  • Compounded Semaglutide helps reduce appetite and supports blood sugar control, making it effective for gradual, medically guided weight loss.
  • It is taken daily or weekly as a capsule, oral strip, or injectable, and is best for adults who are overweight or in need of support for their blood sugar levels.
  • Common side effects are mild and include nausea or bloating; patients should avoid combining it with other weight loss or blood sugar medications.

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How Compounded Semaglutide Works

Compounded Semaglutide works by mimicking a natural hormone called GLP-1 (glucagon-like peptide-1), which plays a role in appetite suppression and blood sugar regulation.1

Its primary effect is to reduce appetite and promote a lasting feeling of fullness, helping individuals eat less without feeling deprived. It also helps improve blood sugar control, which may reduce cravings and support steady energy levels throughout the day.

Over time, this can support significant and sustainable weight loss, especially when combined with a healthy diet and lifestyle. Most individuals begin seeing changes after several weeks of consistent use.

How to Take Compounded Semaglutide

Compounded Semaglutide requires a prescription from a licensed doctor. It must also be taken consistently as instructed to maintain consistent levels of the medication in your system.

Always follow the dosage instructions provided, especially at the beginning of your treatment plan, and never deviate without your doctor’s approval.

If you're using the oral capsule, swallow it whole with a glass of water. Do not crush, chew, or open the capsule, as this may affect how the medication works. 

For oral strips, place one strip on your tongue and allow it to dissolve completely. Avoid eating or drinking for at least 30 minutes afterward to ensure proper absorption.

If you’re taking the injectable version, Compounded Semaglutide is administered weekly subcutaneously, typically in the abdomen, thigh, or upper arm.

It can be administered by a healthcare professional who can also guide you through the steps you need to take for self-administering Compounded Semaglutide.

In case you miss a dose, just continue with your next scheduled dose. Do not take two doses at once to make up for the one you missed.

Who Can Take Compounded Semaglutide

This medication is intended for adults who are classified as overweight or obese and are seeking medical support in managing their weight.2

It may also be suitable for individuals who have not achieved sufficient weight loss through lifestyle changes alone.

Compounded Semaglutide is not recommended for:

  • Individuals with a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2).3
  • Pregnant or breastfeeding individuals.
  • Those with known hypersensitivity to Semaglutide or related compounds.

A medical consultation is essential prior to initiating treatment, particularly for patients with pre-existing medical conditions or those taking concurrent medications.

Side Effects of Compounded Semaglutide

Most patients tolerate compounded Semaglutide well, especially when the dosage is increased gradually as advised.

Common side effects include:

  • Nausea
  • Headache or fatigue
  • Bloating or constipation

If you experience any severe or unusual symptoms, stop taking the medication and consult a healthcare professional immediately.

Medicines You Should Not Use with Compounded Semaglutide

Patients should avoid using other weight loss medications concurrently with Semaglutide unless directed by a healthcare provider.

Caution is also advised when taking the following:

  • Insulin or oral diabetes medications.4
  • Medications that significantly lower blood sugar levels.
  • Corticosteroids and hormonal treatments.

Drug interactions may increase the risk of hypoglycemia or other adverse reactions. Always disclose your full medication list to your trusted doctor before starting treatment.

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Article References

[1] Kommu S, Whitfield P. Semaglutide. National Center for Biotechnology Information. Updated February 11, 2024. Accessed April 16, 2025.

[2] Are weight loss medications, like Wegovy, right for you? UC Davis Health. Published September 13, 2023. Accessed April 16, 2025. 

[3] Semaglutide. DrugBank. Accessed April 16, 2025.

[4] Semaglutide Interactions. Drugs.com. Accessed April 16, 2025.

 

About the Medical Reviewer

Photo of Dr. Angelique Tongson

Angelique Tongson, MD

Dr. Angelique Tongson is a licensed general practitioner who passed the October 2024 Physician Licensure Examinations. Currently, she is practicing as a general physician and is committed to delivering patient-centered care.